It's an 01 Yukon Denali. No power loss or noticeable issues when driving.
The light comes on at different times. It's come on at first start up and also in the middle of a drive, not any hard accels. The misfire monitors start counting as soon as it's started, warm or cold.
I haven't done a compression test, mainly because the misfire moves, it's not specific to any cylinder(s). This is leading me to believe it's a fuel related issue, which is why I was checking pressure and watching the fuel trims, which all seem to be within spec from what I've found.