ozium will work, but they make a disinfectant spray just for this situation. i forget the name of it, but explain it at the parts store and im sure they can point you in right direction. but as mentioned, your air system pulls its air from the base of your windshield, on the outside of vehicle. i never had to do this on my yukon so not 100% which side of truck the vent is on, but look around, im sure youll find it. you may have to pop the hood, im not sure. but turn your ac on full blast and spray the stuff in until its entering the vehicle(youll smell it, smells kinda like baby powder) and youre satisfied. then turn the ac off and let the stuff sit in there for a little while. repeat as needed.