There's a few different schools of thought about that. The advertising hype would say to go synthetic no matter what the mileage. There's way more marketing than science behind all of these motor oils.
Then there's the crowd that says if it got that far on regular oil then stick with it. Truth about regular oil these days is that it's way better than it was a decade ago. No doubt about that. If it is changed at steady intervals it should be more than adequate and tolerate more abuse than the non-syn oil from way back when. Most of what you will see on the shelf today for synthetic is a blend. Sythetic oil is made partially from recycled oil as it is. It's all pretty darned good stuff.
If you want to spend the money on synthetic I would. I went with Mobil 1 at 125k on a (probably) highly abused, duty driven cop Tahoe.
Anything over 100k I have an expectation of sudden failure for any drive train component. That being said, why not try to get the most out of it and go with the better synthetic? For the tranny I plan on going with Royal Purple. The guys on here rave about it.
As always, your mileage may vary.