Total bummer.......It's a 6.2 with the 10l80. I just didn't know how integrated the transmission portion was in the tune and if whatever transmission I had mattered. I'm planning on keeping the 6.6 stock as it's the family grocery getter/tow vehicle. Wish I could get away with just the pushrod (ordered one before I scoped the lifter just in case) but no dice.
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On my 2017 6.2L with the 8 speed, I can change anything I want on the engine side. Yours should be the same I would assume. In my opinion, it would be $600 well spent. The new transmissions require getting unlocked via HP Tuners somehow - not sure if the 10 speed is cracked yet or not. You can also go to HP Tuners website and see what is supported on your model year as well.