... '08 Tahoe 224,000 miles ... no major issues ... regular maintenance when needed.
... What if any should I replace (tranny, engine)?
or just keep doing what I've been doing to keep her on the road?
If you have any specific suspicions or concerns, by all means, speak on them.
Lots of experiences here for you to benefit from, but if you say nothing ...
Assuming no specific issues, check the condition of your fluids.
What others call 5 year coolant, I call 3 year coolant. Think the same way for other fluids:
oil, ATF, rear axle / front differential, power steering, brake fluid
If you change fluids a lil bit more often than GM suggests, it can only benefit your vehicle's longevity.
The Murphy's Law-pessimist might prepare by buying parts in advance:
H2Opump, radiator & fans
fuel pump, charcoal canister
check anything you haven't addressed in at least 3 years