My stance is that disabling AFM via tune only or a full mechanical AFM delete will impact the transmission, but in a good way.
The engine jumping between V4 & V8 is troublesome for the TCC and transmission in general;
it generates more heat and unnecessary friction on the wear parts inside the transmission.
It's also GM's stance, on two different subjects.
Engine Half@$$ (I've no respect for V4 mode) isn't good for the engine or the transmission.
It trades engine longevity & durability for not enough MpG.
GM tunes the torque converter clutch behavior differently between civilian / 1500 vehicles vs heavier duty vehicles.
GM does not want civilian customers to feel or notice the TCC locking or unlocking,
so 1500 vehicles have the TCC tuned to slip by GM OE.
Heavier-duty vehicles not only avoid Engine Half@$$ (and 'Cylinder Confusion'),
they also do not bother slipping the TCC lockup or release to try to soften or hide it.
A more thorough aftermarket tune (among MANY other things) 'borrows' this heavier-duty TCC behavior,
which increases transmission durability & longevity, especially when combined with ATF servicing.
Disabling Engine Half@$$ is a GREAT IDEA in and of itself; it improves the engine's odds of lasting much longer,
but if this disablement is done with a plug-in, the light-duty TCC slip is left as is.
Although disabling Engine Half@$$ helps the transmission too, it can never help as much as a thorough tune.