Here's what I found
I've got a 2003 z71 tahoe with the 5.3 flex, and here's what I found with E-85. When I run regular fuel, I get about 14 city, 18 hwy. When I run E-85, I get the same 14 city but only about 14 hwy. I mostly do city driving, so for me it works out better, but if I did any hwy driving, I'd really have to think about using it or not.