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It may rub, or may not. Belltech did a NNBS Avalanche with 4" of front drop with 305/45/22 tires and had 0 problems.
And in general, thats a taller and wide tire than you plan, but then again you could just go 295/35/24 tires and be safe?
I get some rubbing on hard bumps and when i turn lock to lock. I'm alos running the same size tires as you. I'm also a little lower then you,so shouldnt be a problem.
Rear is cake. I'm running drop front a-arms and wasnt all that bad. Spindles cant be any different then the a-arms. To be honest, its been over a year since i isntalled it, so cat really remember. I work on cars all day long, so hard to remember.