10 speed has been a huge upgrade from the 8 speed in my 15 Denali... have an 18 Denali now both Denalis had/have the 6.2L. Used to have a 15 XL SLT with the 5.3L and 6 speed. Both my 6 speed and 8 speed transmissions sucked... the 6 speed would randomly clunk on shifts up or down and the 8 speed failed at 175k. Didn't keep the 15 XL 6 speed past 60k miles so who knows what happened to that transmission. The 10 speed in my current Denali is much smoother. 85k miles on it now and no concerns yet. However 2018 was the first year for the 10 speed so we will see longterm life in the coming years.
As far as MPG goes... both the 6.2L's I've had get better than the 5.3L I had in the XL (Could just be that my Denalis are the short wheelbase vs the 5.3L was long wheelbase.. less weight in the shorter ones). Decently flat highway in summer months I can get 24 mpg cruising 75-80mph in the Denali as where my 5.3L would be just over 20 mpg (but again more weight than the Denali).
Know two individuals who had 6 speeds (with 5.3L) fail in their Suburbans right before 80k miles. One was a 16' and one was a 17'. Some threads on here about dealing with thermostat issues that cause these failures. Unsure if there were any modifications in the later years to prevent failures.
An interesting side note is that GM dumped the 5 year 100k powertrain warranty after 2015 models for a 5 year 60k powertrain warranty in 2016... funny how the 6 speeds were failing before the 100k mark after that. Thought I heard some rumblings a while back that GM knew these transmissions failed and did that on purpose.. but who really knows.
Some additional edits: If you're gonna tow or have substantial weight in the back of the truck... I always use two-haul mode. Much better on the transmission.
As far as the 5.3L vs the 6.2L... after having the 5.3L then the 6.2L I would go with the 6.2L all the way. More power and takes less to get the truck moving. Fun to drive too if you like to get on it every once and while like I do
.With a surfboat too.. the added power makes it easier to tow around town. While it will take premium fuel (vs regular in the 5.3L)... the few extra dollars every fill up are worth it to me.
This is just my two cents and by no means is it all right... just my experiences I figured I would share!