Mine's a 2003. I haven't had any engine or tranny issues, but a few oil leaks, new fuel pump, shocks, brakes...nothing any car that age wouldn't be expected to need, though.
Check the maintenance record on any rig you look at. Especially watch for a fuel pump (if not already replaced they are pretty much gauranteed to die eventually), shocks (air ride system can be expensive to replace, so see if has been recently updated with new shocks and/or compressor or had the air-ride deleted altogether already; if not, expect that it will need to be fixed/replaced fairly soon), and check the tranny for issues.
As for mileage, I get about 13 combined in the winter, with a lot of auto-start idling to warm up. Summer I get close to 15 combined, and typically hit 17-18mpg on highway drives if I'm babying the throttle. Any big hills, head-winds, or a lot of slowing down/speeding up traffic can greatly skew the mileage, though. I've driven into a strong headwind that brought me down to 8-9mpg. These things aren't exactly slicing through the air....lol.