Update so far:
The Tennessee Tune-Up was not exactly successful. Drained the old oil. Put in 5 new quarts, plus a quart of MMO. My truck wouldn't allow me to to get the RPM above 3500 in Neutral, but I let it idle normally for about 10 minutes, then revved it to 3000 RPM for about 5 minutes. Drove it around 20 miles as hard as I could in the city and interstate.
There's always the "ticking/light knocking" sound, and then intermittently, especially if I'm just holding the same speed on the interstate, there's a loud knocking. But as soon as I accelerate, even slightly, the knocking goes away. Youtube video of this below.
When I accelerated ******* the way home, it FINALLY threw a code for the CEL. Misfire on cylinder 6 (the same one I replaced the coil and spark plug on). But now also a P219B, which is a fuel trim cylinder balance code. I did notice that when trying to accelerate while around 20-30mph, it would not respond at all, and then almost "buck" into action.