Yes. I've never looked that much into the exhaust on the GMT800 or 900 so I don't know what's between the manifolds and Y-pipe merge. I know the main thing that's really watched for is the main cat just in front of the muffler. I know there are O2 sensors on each bank as they are needed to monitor the A/F ratio. I could be wrong, but I don't believe there are sensors monitoring the efficiency of the pre-cats, if there are any. Regardless, your state might be tight on any modifications and may know what your truck came with and what should be there. If it has pre-cats and if they inspect for it, I'd cut 'em off the stock piping, hollow them, open the holes to slip over the SpeedTech Y-pipe, and weld the empty shells wherever they'll fit. This way, you'll pass visual and the hollow shells will still have the Y-pipe smoothly going through them. Place O2 sensor bungs/sensors wherever they fit and look appropriate, but turn off their codes in the tune. Except, of course, the O2 sensors that the PCM actually uses to monitor each bank. "High-flow" cat is a bit of a misnomer in the sense that the factory cats are essentially "high-flow". OEM and aftermarket cats are all made up with a tubular matrix of catalyst. It's just that some cheaper aftermarket cats have a lower grade catalyst that may not be sufficient. None of this matters for the pre-cats if they're not monitored. Just crawl under there and take a peek at the layout. Be aware that some flex joints are mistaken for the small pre-cats.
*EDIT*
Curiosity owned me: My '08 has no pre-cats or a single cat just in front of the muffler. It has an '02 sensor after each manifold collector (obviously to monitor A/F ratio), a cat on each leg of the Y-pipe after those monitoring O2s, an O2 sensor to monitor those cats, then the pipes merge together on the passenger side and continue towards the back to a flex joint, then from the flex joint to the muffler...
I was picturing my S10 exhaust when I wrote the first part and assumed the third-gen LS stuff was similar. Either way, there's relatively easy ways around inspections unless they look to see if the tune has been altered to turn off any emissions-related codes.