... most likely because of sludge build up from lack of oil changes that causes the failure (of V4 mode lifters) ...
1. I changed my oil more than often enough.
Superior oil filtration capable of screening finer particles would also be helpful.
I actually think one has to change the oil so often, because oil filters are not quite good enough at their job.
Unfortunately, oil filters are not more precisely rated (which also keeps them from improving).
Using an oversize filter might be of some help.
Using an oil filter better capable of filtering out unusually finer particles would also help protect the V4 lifters from their weakness.
2. My experience with 'overuse' of V4 mode leads me to surmise that the 'sometimes' cylinders change temperature by enough to wear down their rings and cylinder linings at a faster rate than the 'always' cylinders.
In effect, the 'sometimes' cylinders age more rapidly.
What I'm saying is, instead of simply reactivating V4 mode to its previous settings, it may be wise to alter those settings, so as to keep the 'sometimes' cylinders from getting as cold as GM's original settings allow.
Your mileage may vary.