With the traditional tune, you give us specs on your vehicle, and we build a tune based on our experience with similar vehicles. You will need to have a crank relearn performed (any shop with a Tech II or similar can do this and will charge between $50-$100).
With the cable tune, you will perform datalogs on your vehicle, of which we use to develop your tune. We can take your exact vehicle's driving style, and use of modifications into account. So the tune is more specific. Also, the cable can be used to perform the crank relearn, eliminating the need to find someone to do it for you.