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Might be a DOD or AFM problem causing the fouling of the plug. One of my vehicles would simply get oil all over #1 plug and every 6 months it would start to miss-fire, just replaced the plug and all good to go. Then one day it started to misfire, and I had good compression, spark, and fuel, and what had happened was my DOD lifter collapsed. I bought this kit for $50 to relieve the collapsed lifter, broke the DOD so it would not activate and blocked off the oil passage then had my ECM programmed for $50 to remove AFM/DOD and bought new gaskets and did the whole job for around $200.. It was not a bad job to do, and the next time would go quicker...
Just make a note, if you have a fouling plug on 1, 4, 6 or 7, then chances are you have a lifter going bad...
Here is a video on it. and this worked flawlessly for me.
John