Going to have extra electronics in the truck, flip down monitor, possibly run an Xbox. I also do have a car hauler with lighting and winch..
A couple anecdotes. My '04 Yukon XL is loaded to the gills- Bose system, Entertainment/monitor, electric everything and Sunroof. It has one Group Size 78 battery, which seems sufficient even cranking the 8.1. Spec'd for 145A generator. In any case, your 'down the highway' usage has to fall within about 80% of generator capacity.
My '94 6.5 turbodiesel pickup is spec'd for x2 Group Size 78 batteries due to the huge starter and 21:1 compression ratio. The boxes on the '94 hold a size larger battery, and I have a 12k winch installed so I upgraded all the battery cables with military style terminals and the larger batteries.
Since I have no need for engine-off battery capability, there is no isolator. It's not a bad idea to have one between the tow vehicle and trailer, if the trailer has a larger battery than the small breakaway service battery. If you're going to do sound system competitions or spend long hours in the park with the radio on and engine off, auxilliary batteries and isolator are a must.