I just purchased a 2016 Yukon Denali with the 22" wheel option, along with sunroof, etc. I now have 550 miles on the truck and am not really noticing any 'pressure' issues. The only 'buffeting' type of noise I hear comes from the wing mirrors, normally when at highway speeds; nothing interior. I have driven it in the low 40 mph range extensively after reading this thread, but nothing. I occasionally do hear a slight 'drone' when the truck shifts into V4 mode at those speeds, but again, no perceptible increase in pressure sensations.
Interestingly enough just after my purchase at about 60 miles, I had one episode where my ears 'popped', and I had to swallow to clear them. I was terrified I was going to have the dreaded issues mentioned above, but it was just that one time. My wife has noticed nothing.
I have slight wheel imbalance at around 70 mph and will get that seen to, but so far that's the only issue. Fingers crossed! lol
Bish