I THINK, key word here is THINK, it has to do more with emissions and the intended target market for the engine.
The L8T is only available in HD vehicles which has a substantially different emission regulation and is “better” because of the lesser restrictions
(no Cylinder deactivation/start-stop).
The 5.3L & 6.2L might be more “similar” from an engineering perspective which is why they appear in the regular consumer-grade vehicles,
and the L8T is for HD use only.
**this is a working theory**
Substitute 'fuel consumption' for 'emissions'; the emissions profile for the L8T is substantially similar to the 5.3L & 6.2L,
with a longer stroke and an even longer rod-ratio, for better BSFC than its smaller brethren.
However, due to CAFE testing peculiarities, a 6.6L V8 will never score better MpG vs a 6.2L or a 5.3L.
As for the 'intended' market, there are a substantial number of drivers who would drive even more conservatively with a larger engine MOST of the time,
while appreciating an engine that would last far longer, yet still be ready to work (or play) harder when asked,
than an engine busy pretending to be smaller than it is by using less than 8 cylinders.
Cylinder valve deactivation is not for us - it's for CAFE. By the same token, the L8T is kept from most of the civilian population.
(Separate question: why can't civilians have rubber floors that take 5min to clean with running water, as an OPTION?)