If you have the money to spare, and the time to replace them, than any time after 100k would be just fine. Most people on this site ( just seems this way by reading the threads) will wait until they get a code or start having problems before they do anything. I believe that is the wrong way to think. Preventive maintenance is a great thing, because peace of mind is priceless. There is nothing better than starting a 3k road trip knowing that most of your bases are covered. Also, fuel pumps should be replaced after 100k, again, why wait until it strands you hundreds of miles away from home? Hub bearings are good to 100k, but a bunch go out before that and some hang in there for much longer.....why wait? Tires, how many for you guys run them to the markers? how about until the belts show it spots? non of you will admit to it, but again why wait. Breaks are no different, why wait until they start to squeal, changed them early and save your rotors. preventive maintenance will save you money in the long run.