We have guys on here with over 400K on their original AFM-equipped 5.3's. I'd be more inclined to troubleshoot the one you have. Misfires can come from multiple causes, and #8 is not an AFM cylinder, so I'd look at the wiring to the coil and injectors next. The AFM cylinders are 1,4,6,7. Also, are the plugs you're using either OEM or NGK from a known source like Rock Auto or a local parts store? Amazon and eBay are rife with fakes.
Are there any knocking noises accompanying this misfire? Are there any other stored codes when it happens?