No need to replace the core supports and the new radiator should include them anyway in case yours are rotted out, but I doubt it. And if you buy a direct-fit OEM radiator, you won't have to mess with adding any restrictions to the bypass tube, etc. But I would replace the coolant tees at the firewall if you haven't already, along with the heater hoses and wye, since you didn't specifically mention those. The correct one for the Yukon Denali that will match the original in core thickness is this one:
https://www.summitracing.com/parts/dnp-221-9514 Note that Denso is the OEM manufacturer for GM also.
Nearly all of the others listed as fitting it on sites like RockAuto, Autozone, etc actually have a thinner than OEM 1" core. But I measured my core when I replaced the one in my '07 and it's 1.3" thick.