If you are doing it for cost, it depends on how many cents per mile it costs to run each fuel.
I would not run E85 during the winter, it ought to be E70 for winter but can still be hard to start.
The motors love E85 and take 5 tanks or so to get fully acclimated to it. The engine makes more power, idles smoother, cooler and even the transmission runs better. It's literally like cheap race gas. Oh, it's also a great injector cleaner.
When we are not planning to travel, we run E85. If we need the range, we run 93. I never intentionally run low octane fuel.
Here are the stats for my Yukon XL with the 5.3 motor:
You can see that for all city driving and 70% highway driving for a tank of fuel, the mpg difference is about 20%. Eventually, the faster you go the greater the spread between the two fuels cost wise.