Thanks for the reply. My setup is a Kenwood DNX9140 H/U, a RF T600-4 going to 4 6.5" Infinity Kappa Perfect Components, and a RF T1500-1bd going to 2 12" T1's wired @ 2 ohms. I have 0/1awg running to the back with a distribution block with 4awg running to the amps. The grounds are 4awg from the amps going into a distribution block then 1 0/1awg grounded on one of the seat studs.
I know I didn't pinch the wires (unless I zip-tied them too tight) anywhere or catch them on anything. I think there may be interference from the power b/c if I move that RCA around close to the power wire it gets worse. The only thing that doesn't make any sense is that if I move the other RCA, that I'm not having any problems with, close to the same power wire it doesnt have any affect. I made sure the connections were tight (I even squeezed a few of the shields so they would fit tight). I re-wired my H/U with a new power and ground.
Here's a quick diagram that I drew of how I ran the wires: