Not completely. I installed 4 ohm resistors on the tweeters which reduced the hissing significantly (not even noticeable now) but I still haven't found a new ground for the amplifier. Another thing I found out is that the DSP and amplifier should be using the same ground and they're not. I'm using the stock subwoofer mounting studs for the amplifier mount so I've either got to figure out some other way to mount the amplifier or drill a hole in the body for a new ground which I'm not keen on doing.
I've kinda put it off because it's been rainy, cold, or both around here lately and after our trip in this truck my wife sat in the back for a while and complained she couldn't hear the sound so I bought a mini amp to run the tweeters so I can run rear speakers so I've also got a find a place to mount that! And I'm going to build a new sub box that will go between the second row seats so all the rear area is usable. I've also got to figure out some sort of distribution block for the positive cable so I can also run the DSP and second amplifier off the same power cable. I've just been focusing on tuning my other vehicle and learning REW. Plus, on our trip the amplifier started popping and going into protection mode occasionally which has now gotten worse and it appears there might be a short somewhere in the speakers so I've started disconnecting them one by one to see which one is causing it.
As far as making this work with the factory radio, and DSP will be required. There would be no point in doing all of this if it couldn't be tuned. Before I did the rough tune on this truck it did not sound very good. After I get my crap sorted out I will be installing a system in my father-in-law's 08 Sierra Denali and we're going to use a Dayton DSP which was very reasonably priced. If you're not worried about rear speakers then it's a good option. The factory radio has 5 channels of output because it can play 5.1 surround sound DVD's so at a minimum you have to use the front speaker outputs and subwoofer outputs from the radio. If you want rear speakers you'll need a DSP capable of six channels of input.