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the distortion might be because you are putting to much power to your speakers
Where is your HPF set on the 4ch?
Not saying the amp is at fault. Just saying the Infinity's seem to be a bit more "touchy" and susceptible to noise if everything isn't just right.
The amp will have a built-in crossover with a HPF (High Pass Filter). Since you have subs in the truck, I'd set the HPF on somewhere around 60-80Hz. This will keep the lower frequencies from going to the smaller mid drivers and working them so hard, helping with distortion.