OK maybe not. I have the NV249 tcase and there's an issue with the input shaft fitting the 4l80. There was a member on performancetrucks.net that made an adapter but it looks like he only does it if you send your case to him now and it's like $650 plus shipping plus 4 weeks. Once again I'm considering one of the built 4l65e's that supposedly will take 650 hp.
@sumo bought one for his blown Tahoe. I'd like something that just bolts in and will take the power since this is my DD.
Edit: further research has led me to this place
https://transmissioncenter.net/shop/4l60e-to-4l80e-conversion-kit-tahoe-hummer-2-pickup-others/ that sells a conversion kit for my truck to mount up an 80e to my tcase , engine and ecm for $1264 and I'd still need the transmission. And a built 80e is another $3000 -up.