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going from 3.73 to like 4.10 gear you will notice your fuel consumption greatly increases i never recomend gears like a 4.10 unless using the vehicle to tow a heavy trailer or extreme offroad applications or strictly drag racing
my last truck had 4.10 gears and now this tahoe i have has 3.42 gears i totally notice the difference the mileage is alot better plus driving down the highway at 75 my engine isnt tached out like my truck used to do