did the throttle body help? I've seen a lot of threads about them helping with throttle response when replaced. I've been curious if it helps much on the hybrids since they do have a bit of delay on the throttle, atleast mine does.
as for the missfire count, I don't do a ton of drivability trouble shooting, but depending on the car and software, if it's not increasing the number while it's running, I don't know that the history count really tells you everything, it's a bit random. if you can watch the missfire live data while it's missing, that would insure it's #5. if it will miss fire a idle, you can do the old school test of pulling the injector plug off, and see if the engine runs worse or not. if nothing changes, you know it was that cyl missing. if it runs worse, than that cyl was firing. you can pull the plug was too, but normally that will shock you haha. so not recommend without a tool.
for the hissing, most mechanic shops have a smoke machine, it pumps a harmless smoke into the intake and shows any leaks. your shop might be able to do that for you..
the injector data in the scanner is telling you the amount of time ecm is commanding the injectors to open. it can show you if for some reason they aren't all the same, or if more or less at idle than expected, that there's a something telling the ecm to add or subtract fuel. but it doesn't really tell you much about the injector itself. it can be clogged or damaged without the ecm knowing about it. there's places you can take them that will clean and flow test them. depending on the cost, sometimes just replacing them is pretty close to the same money. I'd hate to see you just throw money at them and it not be it thou, that's why I was asking what the spark plugs look like, for signs of to much fuel running rich, or super clean like they just came out of the box, meaning it's a lean miss. also how the fuel pressure acts after the engine is off, in hopes you can see if they are leaking down by losing pressure pretty quickly.
it's all just in the hopes of seeing something wrong without spending money on parts that don't fix it. I hate doing that lol, and feel bad watching other people do it.
but in the end, nothing beats having a good mechanic look at it in person. only so much you can do online.